---
title: E-Prescribing Message Flows (R.318)
slug: eprescribing/guide/e-prescribing-message-flows-r318
docTags: 
createdAt: 2026-07-09T19:51:50.521Z
---

# Overview

This section holds the application certification requirements located in the [E-Prescribing Message Flows](docId\:Cad-BYiNqbmdCzN2jgVkS) section in the guide.

## R.318

**R.318**: Customers shall support the mandatory messages detailed in the Message Flow section of this guide per customer (Long Term and Post Acute Care (LTPAC) and non-LTPAC) settings and services:

***E-Prescribing Messages for non-LTPAC:***

**Required**: NewRx; RxRenewalRequest/RxRenewalResponse; RxChangeRequest/RxChangeResponse; CancelRx/CancelRxResponse

***E-Prescribing Messages for LTPAC*****:**

**Required**: NewRx; CancelRx/CancelRxResponse; RxFill; RxFillIndicatorChange (pharmacies); Census; Resupply